Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENaphazolinenitrateCat.No.:HY-111326ACASNo.:5144-52-5Synonyms:Naphthazolinenitrate分?式:C??H??N?O?分?量:273.29作?靶點(diǎn):AdrenergicReceptor;TNFReceptor;InterleukinRelated;VEGFR作?通路:GPCR/GProtein;NeuronalSignaling;Apoptosis;Immunology/Inflammation;ProteinTyrosineKinase/RTK儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1monthBIOLOGICALACTIVITY?物活性Naphazoline(Naphthazoline)nitrate?種α-腎上腺素能受體(α-adrenergicreceptor)激動(dòng)劑。Naphazolinenitrate能降低?管通透性和促進(jìn)?管收縮。Naphazolinenitrate可降低炎癥因?(TNF-α、IL-1β和IL-6)、細(xì)胞因?(IFN-γ和IL-4)、IgE、GMCSF和NGF的?平。Naphazolinenitrate可?于?細(xì)性結(jié)膜炎的研究。IC50&TargetIL-1βIL-6IL-4體內(nèi)研究Naphazolinenitrate(0.2mg/kg,10μlpereye;IP,once)reduceshistamineorantigen-inducedconjunctivalvascularhyperpermeabilityinmice,andreducesconjunctivitisinmiceviaeffectsoninflammation,NGFandVEGF[1].AnimalModel:Femalewild-typeBALB/cmice(4-5weeks,18±2g,n=8/group,allergicconjunctivitismousemodelestablishedusinghistamineoranantigen(ovalbumin))[1]Dosage:0.2mg/mL,10μlpereyeAdministration:Intraperitonealinjection(IP),once1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEResult:inigfitljuticulajuertiit.duindicflaithtoiseaintiosighenlevelsofIL-1β,IL-6,IFN-γ,andIL-4.ReducedthelevelsofIgE,GMCSF,NGFandVEGFinantigen-inducedconjunctivalvascularhyperpermeabilitymice.REFERENCES[1].QuanL,et,al.Treatmentwitholopatadineandnaphazolinehydrochloridereducesallergicconjunctivitisinmicethroughalterationsininflammation,NGFandVEGF.MolMedRep.2016Apr;13(4):3319-25.[2].YamaguchiI,et,al.Centralandperipheraladrenergicmechanismsregulatinggastricsecretionintherat.JPharmacolExpTher.1977Oct;203(1):125-31.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-