Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(+)-JQ1PACat.No.:HY-112789CASNo.:2115701-93-2分?式:C??H??ClN?OS分?量:437.95作?靶點(diǎn):EpigeneticReaderDomain作?通路:Epigenetics儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)Ethanol:50mg/mL(114.17mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.2834mL11.4168mL22.8337mL5mM0.4567mL2.2834mL4.5667mL10mM0.2283mL1.1417mL2.2834mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性(+)-JQ1PA溴結(jié)構(gòu)域和額外末端結(jié)構(gòu)域(BET)抑制劑JQ1的衍?物，其IC50值為10.4nM。IC50&Target10.4nM(BET)[1].體外研究(+)-JQ1PAisaderivativeofJQ1,whichistheinhibitorofBET.TheIC50of(+)-JQ1PAforBETis10.4nM,1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEandtheIC50ofJQ1is14.3nMinMV4;11cells[1].PROTOCOLCellAssay[1]ProliferationofMV4;11cellsafter72hoursoftreatment,comparingJQ1versusJQ1-PAaretested.CellcycleprofileofMV4;11cellsafter48hoursoftreatmentwithDMSO,JQ1,JQ1-PA,orJQ1-TCO(allcompoundsusedat500nM)aretested[1].MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly.REFERENCES[1].TylerDS,etal.Clickchemistryenablespreclinicalevaluationoftargetedepigenetictherapies.Science.2017Jun30;356(6345):1397-1401.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>