Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(Rac)-IndoximodCat.No.:HY-133897CASNo.:26988-72-7Synonyms:1-Methyl-DL-tryptophan;(Rac)-NLG-8189分?式:C??H??N?O?分?量:218.25作?靶點:Indoleamine2,3-Dioxygenase(IDO);Apoptosis作?通路:MetabolicEnzyme/Protease;Apoptosis儲存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數據體外實驗H2O:33.33mg/mL(152.71mM;ultrasonicandwarmingandadjustpHto10withNaOHandheatto60°C)DMSO:4.76mg/mL(21.81mM;ultrasonicandwarmingandadjustpHto4withHClandheatto60°C)H2O:2.5mg/mL(11.45mM;ultrasonicandwarmingandadjustpHto10withNaOHandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.5819mL22.9095mL45.8190mL5mM0.9164mL4.5819mL9.1638mL10mM0.4582mL2.2910mL4.5819mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。BIOLOGICALACTIVITY?物活性(Rac)-Indoximod(1-Methyl-DL-tryptophan)吲哚胺-2,3-雙加氧酶(IDO)抑制劑。(Rac)-Indoximod和IFN-γ聯?顯著降低了表達α-SMA的??肌成纖維細胞活性，并通過上調IRF-1，Fas和FasL因誘導凋亡(apoptosis)[1]。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIC50&TargetIDO體外研究(Rac)-Indoximod(1-Methyl-DL-tryptophan;0.5mM;3days)inhibitstryptophandepletion,therebypartiallyreversingthegrowth-inhibitoryactivityofIFN-γ,buteventuallyinducescelldeathregardlessoftryptophandepletion[1].CellViabilityAssay[1]CellLine:Humancardiacmyofibroblasts(hCMs)Concentration:0.5mMIncubationTime:3daysResult:GrowthretardationbyIFN-γwaspartiallyreversedonday2,butcellviabilitywasfurtherreducedonday3.REFERENCES[1].Jun-WonLee,etal.Co-treatmentwithinterferon-γand1-methyltryptophanamelioratescardiacfibrosisthroughcardiacmyofibroblastsapoptosis.MolCellBiochem.2019Aug;458(1-2):197-205.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-