Rheumaticandimmunediseasesinchildren智慧樹知到期末考試答案+章節(jié)答案2024年浙江大學JIApatientssuspectedwithmacrophageactivationsyndromeusuallyhavehyperferritinemia.（）

答案:對Rheumaticdiseasesaredefinedasalargegroupofdiseasesthatonlyaffectstheconnectivetissuesofthebodyinthemodernsense.（）

答案:錯IntheACR1997revisedclassificationcriteriaforSLE，arthritisinvolves3ormoreperipheraljoints.（）

答案:錯Kawasakidiseaseisavasculitisthatpredominantlyaffectsthelarge-sizearteries.（）

答案:錯TcellsandTcellsubpopulationscanbeenumeratedbyflowcytometryrecognizingCDantigenspresentonTcells,usuallyCD19orCD20.（）

答案:錯Ifthetotalimmunoglobulinlevellessthan6gramperliterorIgGlessthan2gramperliter,itindicatespossibleantibodydefects.（）

答案:錯Myositis-associatedautoantibodiesarepresentspecificallyinpatientswithidiopathicinflammatorymyopathies.（）

答案:錯TheseverityofpediatricSLEisnotablyworsethanthetypicalcourseforadultonsetSLE.（）

答案:對RegularadministrationofIVIG,400-600mg/kg,issuggestedforhypogammaglobulinemia.（）

答案:對ChildrenwithIgAvasculitismayexperiencerecurrences.（）

答案:對Accordingto10warningsignsofPID,ifthechildhasrecurrent,deepskinabscesseswithafamilyhistoryofprimaryimmunodeficiency，weshouldpayattentiontothepossiblepresenceofanunderlyingprimaryimmunodeficiencydiseaseofthischild.（）

答案:對TheintervalbetweenstreptococcalinfectionandtheonsetoftheclinicalmanifestationsofARFisabout2to3weeks.（）

答案:對Antibioticprophylaxisforpatients,whodidnothavecarditiswiththeirinitialepisodeofARF,shouldcontinueuntilthepatientreaches18yearofageoruntil3yearshaveelapsedsincethelastrheumaticfeverattack.（）

答案:錯OneofthecharacteristicsofKawasakidiseaseisbilateralconjunctivalinjectionwithexudate.（）

答案:錯TheulcersofthetongueandhardpalateinSLEpatientsaretypicallypainless.（）

答案:對Whichofthefollowingarerecommendedasafirstchoiceinthetreatmentofactivemoderatetoseverejuvenilelocalizedscleroderma？（）

答案:Glucocorticosteroids;MethotrexateWhichofthefollowingtestspatientsforT-celldefects?（）

答案:Chestx-rayexamination;Peripheralabsolutelymphocytecount;Tcellsubsetsenumeration;DelayedcutaneoushypersensitivityWhichofthefollowingaresuggestedinsuperficialcircumscribedmorphea？（）

答案:Topicalimiquimod;Topicalglucocorticosteroids;TopicaltacrolimusModeratetohigh-diseaseseverityofJuvenilelocalizedsclerodermaincludes（）

答案:Linearscleroderma;Generalizedmorphea;Panscleroticmorphea;Patientwithdeeplesion,headlesion,orextracutaneousinvolvementWhichofthefollowingareassociatedwithneonatallupus？（）

答案:Anti-Ro/SS-Aantibody;Anti-La/SS-BantibodyWhichofthefollowingtestspatientsforB-celldefects?（）

答案:Bcellnumberdetection;LevelsofserumIgG，IgM，IgA;DetectionofantibodytitersWhichofthefollowingarerightaboutreplacementtherapyofprimaryimmunodeficiencydisease?（）

答案:HigherdosesofIVIGareindicatedinpatientswithchronicorsevereinfections.;RegularadministrationofIVIG400-600mg/kgissuggestedforhypogammaglobulinemia.;Keepingthepatient'sserumIgGat≥5g/Lisgoodforpreventinginfections.Injuvenilesystemicsclerosis，theskingoesthroughseveralphases，including:（）

答案:Induration.;Atrophy.;Edematous.Thepharmacologicaltherapyofsystemiclupuserythematosusincludes?（）

答案:Corticosteroids;Immunosuppressiveagents;Antimalarials;NonsteroidalAntiinflammatoryDrugsWhichofthefollowingareincludedinthedefinitionofEnthesitis-relatedArthritis?（）

答案:PresenceofHLA-B27;Onsetofarthritisinaboyafter6yearsofage;AcutesymptomaticanterioruveitisAcuterheumaticfeveriscausedby（）.

答案:StreptococcuspneumoniaeWhichofthefollowingisNOTacharacteristicofSevereCombinedImmunodeficiency?（）

答案:LargethymusWhichofthefollowingisnotaclinicalfeatureofjuvenileidiopathicarthritis?（）

答案:Migratorypolyarthropathy,recurrentlyoccurWhichofthefollowingisnotthecauseofSLE?（）

答案:BloodtransfusionHydroxychloroquineisanantimalarialdrugimportantinthetreatmentofSLEanddermatomyositis.Whichisthemostsignificantpotentialadverseeffectofhydroxychloroquine？（）

答案:RetinaltoxicityA1-month-oldboyhadrecurrenthypocalcemicconvulsionsafterbirth.Physicalexamination:wideningeyedistance,micrognathism,increasedmuscletoneinextremities.X-rayexaminationshowednothymusshadow.Whichofthefollowingtreatmentsshouldnotbeusedinthischild?（）

答案:CommonredbloodcelltransfusionThefollowingdrugsaregenerallyusedforthetreatmentofKawasakidisease,exceptfor（）

答案:MethotrexateWhatisthetypicalrashofSLEpatients?（）

答案:ButterflyrashWhichtestisthefirstchoicetomonitorfordevelopmentofcardiovascularcomplicationofKawasakidisease.（）

答案:Echocardiography.Whichtestisthefirstchoicetodoforajuvenilesclerodermapatientswhohaveabnormalpulmonaryfunctiontests?（）

答案:HRCT.What'sthedifferencebetweenjuveniledermatomyositisandpolymyositis？（）

答案:TypicalrashA9-year-oldboywasadmittedtothehospitaldueto"feverfor2weeksandjointspainfor1week".Therightshoulderjointwasswollenandpainfulfor3daysandrelievedbyitself.Thenthekneesbeganswollenandpainful.PE:T38℃,slightcongestioninpharynx,nospecialcardiopulmonaryauscultation,swellingandtendernessofbothkneejointswithhighlocalskintemperature,limitationofmotion.Theotherjointsarenormal.Polycyclicredbordersoferythemamarginatumcanbeobservedontheback.Laboratorytests:ESR98mm/h,CRP55mg/L.Whatisthemostimportanttestforadefinitivediagnosisofthispatient?（）

答案:ASOA6-year-oldboywasadmittedtohospitalfor"highfeverformorethan1month",accompaniedbyswellingandpainintherightwristandleftankle.Therashbecameobviouswhenthebodytemperaturerised.Antibiotictreatmentwasfailed.PE:Acongestivepinkrashcanbeseenonthetorso.Cervicallymphnodesenlargement.Nospecialcardiopulmonaryauscultation.Thelivercanbepalpated3cmbelowthecostal,andspleencanbepalpated1cmbelowthecostal.CBC:WBC30×109/L,N85%,Hgb90g/L,CRP95mg/L,ESR120mm/h.ASO,bloodculture,ANAwereallnormal.Themostlikelydiagnosisis:（）

答案:SystemicJIAWhichofthefollowingisnotaprimaryimmunodeficiencydiseasedominatedbyantibodydeficiency?（）

答案:DiGeorgesyndromeWhichimmunoglobulincanbetransmittedtothefetusthroughtheplacenta?（）

答案:IgGRegularadministrationofIVIG,2g/kg,issuggestedforhypogammaglobulinemia.（）

答案:錯AboutX-linkedagammaglobulinemia,whichofthefollowingisNOTright?（）

答案:Antibodytiterswithtetanusareveryhigh.Theimmunesystemintegrates2fundamentalresponsemechanism，innateimmunityandacquiredimmunity.（）

答案:對TcellsandTcellsubpopulationscanbeenumeratedbyflowcytometryrecognizingCDantigens,usuallyCD3,CD4,andCD8.（）

答案:對AboutDiGeorgesyndrome,whichareright?（）

答案:ChestXrayishelpfultodetecthypoplasiaoraplasiaofthethymus.;Absolutelymphocytecountsarelowforage.;Immunoglobulinlevelsareoftennormal.;Reducedparathyroidhormoneandbloodcalcium,elevatedphosphorus.SkinbiopsiesareneededforroutinediagnosisofJuvenileScleroderma.（）

答案:錯Panscleroticmorpheareferstoovalorroundshapelesionsthatarecentrallyinduratedwithawaxy,ivorycolorandaviolaceousrim.（）

答案:錯Juvenilelocalizedsclerodermaislimitedtotheskinandnotaffectsotherorgans.（）

答案:錯ThesignsofdiseaseactivityofJuvenilelocalizedsclerodermaincludeerythemaand（）

答案:Waxywhiteoryellow;Violaceouscolor;DiseaseExtension;TactileWarmthRaynaudphenomenonresultsfrompersistentvasospasmofperipheralarteriesandarterioles,ofteninresponsetocoldorstress.（）

答案:錯KidneyinvolvementisasignificantcauseofmorbidityandmortalityinbothadultandpediatricpatientswithSLE.（）

答案:對ChildrenwithSLE（cSLE）havemoreseverediseaseandmorewidespreadorganinvolvementcomparedwithadults.（）

答案:對KidneyInvolvementofSLEincludes（）

答案:Chronickidneydisease;Isolatedasymptomatichematuria;Nephroticsyndrome;AcutenephriticsyndromeAccordingtotheACR1997revisedclassificationcriteriaforSLE，excludingotheretiologies,presenceof4ofthe11simultaneouslyestablishesthediagnosis.（）

答案:錯WhichautoantibodyisofhighspecificityforSLE?（）

答案:Anti-dsDNAantibody;Anti-SmantibodyTheelectromyographyabnormalitiesarespecificinjuveniledermatomyositispatients.（）

答案:錯Patientswithjuveniledermatomyositisshouldnotdoanyexercise.（）

答案:錯Idiopathicinflammatorymyopathies(IIM)areaheterogenousgroupofdiseasescharacterizedbymuscleweaknessandinflammatorychangesinskeletalmuscle.（）

答案:對Thepathogenesisofjuveniledermatomyositisincludes（）

答案:ImmunologicalMechanisms;Geneticfactors;Infection;UnusualsunexposureWhichofthefollowingarenotincludedintheBohanandPetercriteriaofjuveniledermatomyositis?（）

答案:myositisantibodiesWhataretheorgansofteninvolvedinanaphylactoidpurpura?（）

答案:Kidney;Joints;Gastrointestinaltract;SkinInfantileAcuteHemorrhagicEdemausuallyaffecttheskinandkidney.（）

答案:錯WhatisthecomplicationthataffecttheprognosisintheacutephaseofIgAvasculitis?（）

答案:Gastrointestinal(GI)manifestationsIgAvasculitisischaracterizedbyleukocytoclasticvasculitisandimmunoglobulinAdepositioninthemediumvessels.（）

答案:錯LeukocytoclasticvasculitiswithIgAdepositioninaffectedtissuesisveryimportantinIgAvasculitis.Therefore,patientswithIgAvasculitisneedabiopsytoconfirmthediagnosis.（）

答案:錯What'sthepathogenesisofKawasakidisease？（）

答案:Immune-mediatedvasculitisWhat'stheearliestsymptomsofKawasakidisease？（）

答案:FeverAcuteKawasakiDiseaserecursin1–3%ofcases.（）

答案:對ThedurationoffeverwithouttreatmentofKawasakiDiseaseisusuallylongerthan4weeks.（）

答案:錯Approximately20–25%ofuntreatedchildrendevelopcoronaryarteryabnormalities,whereas<5%ofchildrentreatedwithIVIGdevelopCAA.（）

答案:對Aboutoligoarthritis，whichofthefollowingisnottrue?（）

答案:It’sHLA-B27–associated.Thedefinitionofjuvenileidiopathicarthritisrequiresthedurationofarthritistobe?（）

答案:≥6weeksWhichofthefollowingmanifestationscanoccurinjuvenileidiopathicarthritispatients?（）

答案:Jointswelling;Uveitis;PainandstiffnessofthejointsANAseropositivityisassociatedwithincreasedriskofchronicuveitisinJIA.（）

答案:對Juvenileidiopathicarthrit