1、.,1,Acute Nephritis急性腎炎,Post-infectious glomerulonephritis Post-streptococcal glomerulonephritis,.,2,Acute Nephritis,characterized by: Fluid retention (Edema, Hypertension) Hematuria Oliguria Group A -hemolytic streptococci (history of infection, positive culture/ elevated antistreptolysin title),.,

2、3,gross hematuria（肉眼血尿 ）,microscopic hematuria （鏡下血尿 ）,Cinical features,均一性 / 非均一性,.,4,Pathology,.,5,Normal glomerulus,AGN,Pathology,.,6,Pathology,With infiltration by hematogenous cells, most notably PMNS,.,7,Pathology,In AGN, immunofluorescent studies show finely granular staining for IgG in perip

3、heral capillary loops and in mesangial areas,.,8,Pathogenesis,Nephritis strain（Ag）,CIC/IC,Depositing within glomeruli and stimulate the fixation of complement/antibody,Diffuse proliferative,GBM injury,GFR,oliguria,overload,edema hypertention,Hematuria proteinuria,.,9,Frequency of clinical Manifestat

4、ions in APSGN,Gross hematuria 25 33 % Volume overload Edema 85% Hypertension 60-80% Circulatory congestion 20% CNS symptoms 10% Progressive GN 1%,.,10,Evaluation to Document likelihood of typical poststreptococcal AGN,Complement: decreased during acute phase levels rise toward normal by 6-8 weeks,ES

5、R： rising during acute phase levels return to normal by 2-3 months,Beginning recovery in 1 week: Diuresis Blood presure normalized BUN, cretinine begin to fall,.,11,Diagnosis,Definition Edema Hypertension Hematuria Oliguria Etiology is pursued with a throat swab, antistreptolysin O titre Low complem

6、ent C3 level,.,12,Treatment,Treatment strategy for AGN Bed rest as necessary Fluid and salt restriction Specific intervention for the following Hypertention and other signs of volume overload, including encephalopathy Acidemia / Hyperkalemia / Hyperphosphatemia * Keep high index of suspicion for diseases other than APSGN ( differential doagnosis ),.,13,Prognosis,Most patients recover completely Rarely, a rapid progressive glomerulonephritis with renal failure may occur, especially in nephritis from other causes Diagnostic renal biopsy i