1、肥厚性梗阻型心肌病的外科治療,劉曉程 泰達國際心血管病醫(yī)院 2009-10-10,第二十屆長城國際心臟病學會議 The 20th Great Wall International Congress of Cardiology (GW-ICC),常染色體顯性遺傳疾病 發(fā)病率1/500,1. Per the GeneTests Laboratory Directory 2. Allelic disorders = other phenotypes caused by mutation in the same gene 3. DCM = dilated cardiomyopathy 4. LGMD

2、= limb-girdle muscular dystrophy 5. The consensus of the GeneReview authors is that additional confirmatory data supporting pathogenicity for this gene is necessary.,A. 正常心臟B. HCMC. HCM （馬森三色染色法）,（Images courtesy of Robert Padera, MD Brigham and Womens Hospital Department of Pathology, Boston, MA.）,

3、組織學,癥狀 體征,動作或藥物對HCM的影響,診斷,BrockenbroughBraunwaldMorrow 征,診斷：心電圖,診斷：超聲心動圖,鑒別診斷,MRI,治療策略,成功率,適應證,起搏器治療,經(jīng)皮室間隔消融術(shù),外科治療 HCM,經(jīng)典Morrow術(shù)式,HCM的外科治療,改良Morrow術(shù)式,HCM的外科治療：患者資料,兩種術(shù)式的比較,謝謝！,Surgery for Hypertrophic Cardiomyopathy (HCM),Xiaocheng Liu TEDA International Cardiovascular Hospital China 2009-10-10,第二十屆

4、長城國際心臟病學會議 The 20th Great Wall International Congress of Cardiology (GW-ICC),A autosomal dominant disease. Morbidity of HCM is 1 per 500.,1. Per the GeneTests Laboratory Directory 2. Allelic disorders = other phenotypes caused by mutation in the same gene 3. DCM = dilated cardiomyopathy 4. LGMD = li

5、mb-girdle muscular dystrophy 5. The consensus of the GeneReview authors is that additional confirmatory data supporting pathogenicity for this gene is necessary.,A. Normal heartB. HCMC. HCM with Masson trichrome staining,（Images courtesy of Robert Padera, MD Brigham and Womens Hospital Department of

6、 Pathology, Boston, MA.）,HISTOLOGY,symptoms signs,Effects of Physiologic and Pharmacologic Maneuvers on HCM,DIAGNOSIS,BrockenbroughBraunwaldMorrow Sign,DIAGNOSIS: ECG,DIAGNOSIS: UCG,UCG for differential Diagnosis,MRI,Strategy of Treatment,Success rate,Indication,Pacemaker Therapy,Percutaneous septal ablation,Surgery for HCM,Classical Morrow Procedure,Surgery