1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELevofloxacin hydrateCat. No.: HY-B0330ACAS No.: 138199-71-0Synonyms: Levofloxacin hemihydrate分式: CHFNO . .HO分量: 370.38作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (prot

2、ect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 50 mg/mL (135.00 mM)DMSO : 8.33 mg/mL (22.49 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.6999 mL 13.4996 mL 26.9993 mL5 mM 0.5400 mL 2.6999 mL 5.3999 mL10 mM 0.2700 mL 1.3500 mL 2.6999 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解

3、度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 0.83 mg/mL (2.24 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD

4、in saline)Solubility: 0.83 mg/mL (2.24 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 0.83 mg/mL (2.24 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Levofloxacin半合物抗素化合物，抑制細(xì)菌DNA旋轉(zhuǎn)酶活性。REFERENCES1. Siva, R., et al., Effect of levofloxacin

5、 on neutrophilic airway inflammation in stable COPD: a randomized, double-blind, placebo-controlledtrial. Int J Chron Obstruct Pulmon Dis, 2014. 9: p. 179-86.2. Pradeep, A.R., et al., Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placeb

6、o-controlled clinical trial. J Investig Clin Dent, 2014.3. Lee, B.T., et al., Efficacy of Levofloxacin in the Treatment of BK Viremia: A Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial. Clin J Am Soc Nephrol, 2014.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8