1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEtCFA15Cat. No.: HY-104031CAS No.: 220757-88-0分式: CHO分量: 364.6作靶點(diǎn): Notch作通路: Neuronal Signaling; Stem Cell/Wnt儲(chǔ)存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 130 mg/mL (356.56 mM; Need ul

2、trasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (5.95 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.17 mg/mL (5.95 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 tCFA15 為種三甲環(huán)烯長(zhǎng)鏈脂 醇，側(cè)鏈含有 15 個(gè)碳原，能夠促進(jìn)神經(jīng)細(xì)胞的分化，具有調(diào)控 N

3、otch信號(hào)通路的潛。IC50 & Target Notch1 1體外研究 tCFA15 (10 nM-1 M) dose-dependently affects the differentiation of neural stem cell-derived neurospheres bypromoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 M) specificallydecreases the level of Notch1 mRNA in spheres, and

4、such an effect is also observed in decreases Notch1expression in neuronal and glial cell cultures 1. tCFA15 stimulates arginine vasopressin secretion in nerveterminals of the neurohypophysis 2.REFERENCES1. Bouissac J, et al. tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol, affects neural

5、 stem fate and differentiation by modulatingNotch1 activity. Eur J Pharmacol. 2013 Oct 15;718(1-3):383-92.2. Girlanda-Junges C, et al. 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion. BioorgMed Chem Lett. 2000 Nov 20;10(22):2537-9.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-