Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEltanexorZ-isomerCat.No.:HY-100423ACASNo.:1642300-78-4Synonyms:KPT-8602(Z-isomer)分?式:C??H??F?N?O分?量:428.29作?靶點:CRM1作?通路:MembraneTransporter/IonChannel儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數據體外實驗DMSO:50mg/mL(116.74mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.3349mL11.6743mL23.3487mL5mM0.4670mL2.3349mL4.6697mL10mM0.2335mL1.1674mL2.3349mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據您的實驗動物和給藥?式選擇適當的溶解?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據儲存條件，適當保存；體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.75mg/mL(6.42mM);ClearsolutionBIOLOGICALACTIVITY?物活性EltanexorZ-isomer(KPT-8602Z-isomer)活性較弱的KPT-8602異構體。KPT-8602為?效的CRM1抑制劑。REFERENCES[1].VercruysseTetal.Thesecond-generationexportin-1inhibitorKPT-8602demonstratespotentactivityagainstacutelymphoblasticleukemia.ClinCancerRes.2016Oct25.[2].HingZAetal.Next-generationXPO1inhibitorshowsimprovedefficacyandinvivotolerabilityinhematologicalmalignancies.Leukemia.2016Jun21.[3].EtchinJetal.KPT-8602,asecond-generationinhibitorofXPO1-mediatednuclearexport,iswelltoleratedandhighlyactiveagainstAMLblastsandleukemia-initiatingcells.Leukemia.2016Jun24.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-