NormalBloodCellMorphologyContents123GranulocyteseriesErythrocyteseriesMegakaryocyteseries粒細(xì)胞系統(tǒng)紅細(xì)胞系統(tǒng)巨核細(xì)胞系統(tǒng)Newwords:Cyto-,-cyte細(xì)胞-philic親，嗜Myelo-髓系的、粒系的-blast胚細(xì)胞、原始細(xì)胞Pro-前；meta-，后Mono-單Lympho-淋巴Mega-大、巨型；Karyo-核的nuclear，nucle(o)-MyelocyteMonocytecyteLymphoNewwords:cytoplasm細(xì)胞質(zhì)myeloblast原始粒細(xì)胞nucleus細(xì)胞核promyelocyte早幼粒細(xì)胞nucleolus(nucleoli)核仁myelocyte中幼粒細(xì)胞chromatin染色質(zhì)metamyelocyte晚幼粒細(xì)胞azurophilic嗜苯胺藍(lán)的granulocyte粒細(xì)胞neutrophilic嗜中性的pronormoblast原始紅細(xì)胞eosinophilic嗜酸性的normoblast早幼紅細(xì)胞basophilic嗜堿的erythrocyte紅細(xì)胞Newwords:monoblast原始單核細(xì)胞lymphoblast原淋巴細(xì)胞promonocyte幼單核細(xì)胞prolymphocyte幼淋巴細(xì)胞monocyte單核細(xì)胞lymphocyte淋巴細(xì)胞megakaryoblast原始巨核細(xì)胞plasmablast原漿細(xì)胞promegakaryocyte幼巨核細(xì)胞proplasmacyte幼漿細(xì)胞megakaryocyte巨核細(xì)胞plasmacyte漿細(xì)胞Hematopoiesis（血細(xì)胞生成）Howtoidentifyacell?Cell:size,shape,N:CNucleus(胞核):shape，location,chromatinpattern,nucleoliCytoplasm(胞漿):color,amount,granule,vacuole,inclusionbodyGeneraltrendsthataffectthemorphologyofbloodcellsduringthedevelopmentalprocessQuestion:①②③neutrophilicsegmentedgranulocyteeosinophilicsegmentedgranulocytebasophilicgranulocyteGranulocyteseriesMyeloblast原粒細(xì)胞Promyelocyte早幼粒細(xì)胞NeutrophilicEosinophilicBasophilicMyelocyteMetamyelocyteStabgranulocyteSegmentedgranulocyte晚幼粒細(xì)胞桿狀核粒細(xì)胞分葉核粒細(xì)胞中幼粒細(xì)胞Myeloblast原粒細(xì)胞Size:10-20μmindiameter,roundorovalNeucleus:roundoroval,centraloreccentric,finechromatininreddish-purple,2-5obviousnucleoliCytoplasm:smallamount,transparentskyblueordeepblue,nogranuleorafew(typeⅡ)Promyelocyte(progranulocyte)早幼粒細(xì)胞S:12-25μm,maybelargerthanmyeloblast,roundorovalN:roundorovalorslightlyindented,centraloreccentric,slightlycoarserchromatinpattern,nucleoli:oftenvisibleC:moderateorabundantinamount,containsafewormanyazurophilicgranuleswhicharevariableinsizeandshape,oftenovernucleusNeutrophilicMyelocyte中性中幼粒細(xì)胞S:10-20μm,round,reductioninN:CN:ovalorslightlydistorted,usuallyeccentric,chromatinpatternbecomescoarser,purpleincolor,withoutnucleoliC:abundant,reddishorlightblue,pinkspecificsecondarygranulesmaybeseenaspinkishareasnearthenucleusfirst(barelyvisible)NeutrophilicMetamyelocyte中性晚幼粒細(xì)胞S:10to16μm,roundN:kidneyorhorseshoeshaped,eccentric,withcoarserchromatinpattern,vice-chromatin（副染色質(zhì)）appearsC:abundant,reddish,fullofpinkneutrophilicgranulesNeutrophilic

Stabgranulocyte中性桿狀核粒細(xì)胞S:10to15μm,roundN:bandshaped,U-shaped,S-shaped,coarsechromatin,distinctvice-chromatinC:sameasthemetamyelocyteNeutrophilicSegmentedGranulocyte

中性分葉核粒細(xì)胞S:10to14μm,roundN:usually2to5lobes,connectedbyfilamentsstrandofheterochromatin,coarseclumpedchromatinpattern.C:abundantinreddishwithafullcomplementofrose-violetspecificgranules4kindsofgranulesingranulocytesANeutroEosinoBasoazurophilicdifferentnumber﹠size,irregularlyshaped,oftenovernucleusneutrophilicsmaller,finer,barelyvisibleeosinophilicnumerous,large,uniform,evenlydistributed,suffusingcytoplasmbasophilicfew,large,irregularshape,variableinsize,unevenlydistributed,oftenovernucleusneutrophilic,eosinophilic,andbasophilicgranulocytes;theirmyelocyteprecursorsMyeloidmaturationsequencequestion:RBCErythrocytepronormoblast原始紅細(xì)胞early(basophilic)normoblast早幼紅細(xì)胞polychromaticnormoblast中幼紅細(xì)胞orthochromaticnormoblast晚幼紅細(xì)胞reticulocyte網(wǎng)織紅細(xì)胞erythrocyte(RBC)紅細(xì)胞ErythrocyteseriesPronormoblast（原始紅細(xì)胞）S:15-25μm，sometimespseudopod（偽足）N:Roundtoslightlyoval,central,granulouschromatinstainedreddish-purple,1-3bluishnucleoliC:moderatein

amount,darkblueincolorandopaque,showingtumor-likeprotrusionandadistinctperinuclearpalezone,nogranulesEarlynormoblast（早幼紅細(xì)胞）S:10-18μm,roundorovalN:round,central

chromatinpatternslightlycondensednucleoliarepresent,butnotalwaysvisibleC:moderateinamount,intenselyblueandopaque,perinuclearpalezoneisvisiblePolychromaticnormoblast（中幼紅細(xì)胞）S:8-15μm,roundN:smaller,round,central,chromatinpatternmorecondenseindeeppurplewithdistinctvice-chromatin,givingacartwheel-shapedappearance.nucleoliabsentC:abundantinquantity,polychromatic

ormauvecoluredOrthochromaticnormoblast（晚幼紅細(xì)胞）S:7-10μm,roundN:round,centraloreccentric,pyknoticchromatinpatterninblackpurple,vice-chromatinmayvisibleorinvisible,sometimesextrusionC:abundantinquantity,pinkerthanpreviousstageReticulocyte（網(wǎng)織紅細(xì)胞）largerthanmatureredcellcontainssomeRNAremnants,polychromaticincolor

Erythrocyte（紅細(xì)胞）6-8μmindiameter,7.2μmonaverage,

biconcavedisk,asmallareaofcentralpallor,anuclear,pinkErythroidmaturationsequencestagesofmegakaryocyticmaturation:megakaryoblast（原始巨核細(xì)胞）promegakaryocyte（幼稚巨核細(xì)胞）granularmegakaryocyte（顆粒型巨核細(xì)胞）thrombocytopoieticmegakaryocyte(產(chǎn)血小板型巨核細(xì)胞)nakedmegakaryocyte（裸核型巨核細(xì)胞）platelet（血小板）Megakaryocyteseries

MegakaryocytopoiesisdevelopmentoccursbyendomitosisMegakaryoblast（原始巨核細(xì)胞）S:15-30μm,roundorirregularN:large,roundorirregular.coarsereticularchromatininpurple,2-3vaguenucleoliC:smalltomoderatecytoplasmindeepblue,mayhavepseudopod,nogranulesPromegakaryocyte（幼稚巨核細(xì)胞）S:30-50μm,irregularN:irregularinshape,mayshowslightlobulation,

coarserchromatin,nucleoliindistinctC:moreamountcytoplasmindeepblue,reddish-purplegranulesvisible,pseudopodvisibleGranularmegakaryocyte（顆粒型巨核細(xì)胞）S:giant,

40-70μm,integritymembraneN:giant,

multiplenucleiormulti-lobulation,coarserpatchychromatinpatternC:veryplentifulcytoplasmfullofpurplegranulesThrombopoieticmegakaryocyte（產(chǎn)血小板型巨核細(xì)胞）S:40-70μm,irregular,blurredmembraneN:giant,extremelyhyperploidnucleioftenoverliewithclumpedchromatinC:veryplentifulcytoplasminreddish,granulesclusterandbudofftobecomeplateletPNaked

megakaryocyte（裸核型巨核細(xì)胞）AmaturemegakaryocyticnucleuswithoutcytoplasmPlatelet1–4μmindiameter,givingastar-likeappearance,anuc