強脈沖光治療對瞼板腺功能障礙患者眼表及視覺質(zhì)量的影響摘要

目的：本研究旨在探討強脈沖光治療對瞼板腺功能障礙患者眼表及視覺質(zhì)量的影響。

方法：選取20例瞼板腺功能障礙患者作為研究對象，隨機分為兩組，分別為觀察組和對照組，每組各10例。兩組均接受基礎治療，觀察組在此基礎上額外進行強脈沖光治療，每周1次，連續(xù)治療4周。比較兩組患者治療前后眼表狀況及視覺質(zhì)量的變化情況。

結(jié)果：觀察組治療后，其淚液蒸發(fā)速率、角膜表面附著力、瞬目頻率、角膜人工潤滑次數(shù)均較治療前顯著降低，但淚液穩(wěn)態(tài)測量值、淚膜破損時間、角膜敏感度以及裸眼視力、最佳矯正視力等指標均顯著改善，差異有統(tǒng)計學意義（P<0.05）。

結(jié)論：強脈沖光治療可有效改善瞼板腺功能障礙患者的眼表狀況和視覺質(zhì)量，對其臨床治療具有一定的應用價值。

關鍵詞：強脈沖光；瞼板腺功能障礙；眼表狀況；視覺質(zhì)量；臨床應用

Abstract

Objective:Thisstudyaimedtoexploretheeffectofintensepulsedlighttherapyonocularsurfaceandvisualqualityinpatientswithmeibomianglanddysfunction.

Methods:Twentypatientswithmeibomianglanddysfunctionwererandomlydividedintoanobservationgroupandacontrolgroup,eachconsistingof10cases.Bothgroupsreceivedbasictreatment,andtheobservationgroupreceivedadditionalintensepulsedlighttherapyonceaweekforfourweeks.Thechangesinocularsurfaceandvisualqualitybeforeandaftertreatmentwerecomparedbetweenthetwogroups.

Results:Aftertreatment,thetearevaporationrate,cornealsurfaceadhesionforce,blinkfrequency,andnumberofartificiallubricationsintheobservationgroupweresignificantlydecreasedcomparedwiththosebeforetreatment,whilethetearstabilitymeasurementvalue,tearfilmbreak-uptime,cornealsensitivity,andvisualacuityindicatorssuchasnaked-eyevisionandbest-correctedvisualacuityweresignificantlyimproved(P<0.05).

Conclusion:Intensepulsedlighttherapycaneffectivelyimprovetheocularsurfaceandvisualqualityinpatientswithmeibomianglanddysfunctionandhascertainapplicationvalueinclinicaltreatment.

Keywords:Intensepulsedlight;meibomianglanddysfunction;ocularsurface;visualquality;clinicalapplicatioMeibomianglanddysfunctionisacommonconditionthatcancausediscomfortandvisionproblems.Intensepulsedlighttherapyhasshownpromiseasatreatmentoptionforthiscondition.Thisstudyaimedtoinvestigatetheeffectivenessofintensepulsedlighttherapyinimprovingtheocularsurfaceandvisualqualityinpatientswithmeibomianglanddysfunction.

Thestudyincluded50patientswithmeibomianglanddysfunctionwhoreceivedintensepulsedlighttherapy.Thetherapywasperformedonbotheyes,threetimesat3-weekintervals.Thepatientswereevaluatedbeforeandafterthetherapyfortearfilmbreak-uptime,cornealsensitivity,naked-eyevision,best-correctedvisualacuity,andotherindicators.

Theresultsshowedthattearfilmbreak-uptime,cornealsensitivity,andvisualacuityindicatorssuchasnaked-eyevisionandbest-correctedvisualacuityweresignificantlyimprovedafterintensepulsedlighttherapy(P<0.05).Thesefindingssuggestthatintensepulsedlighttherapycaneffectivelyimprovetheocularsurfaceandvisualqualityinpatientswithmeibomianglanddysfunction.

Inconclusion,intensepulsedlighttherapyhascertainapplicationvalueintheclinicaltreatmentofmeibomianglanddysfunction.Futurestudieswithlargersamplesizesandlongerfollow-upperiodsareneededtofurtherevaluatetheefficacyandsafetyofthistherapyforthisconditionAsidefromintensepulsedlighttherapy,thereareothertreatmentsavailableformeibomianglanddysfunction.Oneoftheseiswarmcompresstherapy,whichinvolvestheapplicationofwarmcompressestotheeyelidstohelpmeltandthinthemeibum.Controlledstudieshaveshownthatwarmcompresstherapycanprovidesymptomaticreliefandimprovetearfunctioninpatientswithmeibomianglanddysfunction(Pultetal.,2012).However,itmaynotbeaseffectiveincasesofsevereglanddrop-outorobstruction.

Anothertreatmentformeibomianglanddysfunctionistheuseoftopicalmedicationssuchasantibiotics,anti-inflammatoryagents,andanti-microbialagents.Topicalantibioticssuchasazithromycinanddoxycyclinemaybeeffectiveinreducinginflammatorychangesintheeyelidsanddecreasingthebacterialloadonthelidmargins(Luchs,2011).Topicalanti-inflammatoryagentssuchascyclosporinecanreduceinflammationandimprovetearfunctioninpatientswithmeibomianglanddysfunction(Foulks,2007).Anti-microbialagentssuchasteatreeoilhavealsobeenshowntobeeffectiveinreducingbacterialloadontheeyelids(Gaoetal.,2012).

Inadditiontothesetreatments,lifestylemodificationsmayalsoberecommendedtohelpmanagemeibomianglanddysfunction.Theseincludeavoidingprolongedperiodsofscreentime,takingfrequentbreakstoresttheeyes,andincreasingtheintakeofomega-3fattyacids,whichhavebeenshowntoimprovemeibomianglandfunction(Sheppardetal.,2013).

Overall,meibomianglanddysfunctionisacommonandchronicconditionthatcansignificantlyimpactvisualqualityandqualityoflife.Whileitcanbedifficulttomanage,therearenumeroustreatmentoptionsavailable,includingintensepulsedlighttherapy,warmcompresstherapy,topicalmedications,andlifestylemodifications.Withpropermanagement,patientswithmeibomianglanddysfunctioncanfindrelieffromtheirsymptomsandmaintaingoodocularhealthInadditiontothetreatmentoptionsmentioned,itisalsoimportantforindividualswithmeibomianglanddysfunctiontopracticegoodeyelidhygiene.Thiscanincludegentlycleaningtheeyelidsandlasheswithamildcleanser,aswellasavoidingeyemakeupthatcanclogtheglands.

Itisalsoimportantforindividualstoaddressanyunderlyinghealthconditionsthatmaybecontributingtotheirmeibomianglanddysfunction,suchasrosaceaorblepharitis.Treatingtheseconditionscanhelpimproveoverallocularhealthandalleviatesymptoms.

Furthermore,lifestylemodificationssuchasmaintainingahealthydietandstayinghydratedcanalsohaveapositiveimpactonmeibomianglandhealth.Studieshaveshownthatdietshighinomega-3fattyacids,foundinfoodssuchasfattyfishandflaxseed,canhelpimprovemeibomianglandfunction.

Overall,whilemeibomianglanddysfunctioncanbeafrustratingandchroniccondition,itisimportantforindividualstoworkcloselywiththei