1、科特壯 犬貓疾病支持治療藥物 劉久占德國(guó)拜耳,The Power of Pink,支持治療,支持治療是指與特異性療法配合的附加治療, 它可以縮短犬貓疾病的康復(fù)時(shí)間！,支持治療,支持治療是指與特異性療法配合的附加治療, 它可以縮短犬貓疾病的康復(fù)時(shí)間！,支持治療對(duì)犬貓的重要性,一般來說，疾病會(huì)降低犬貓新陳代謝機(jī)能，而新陳代謝機(jī)能降低又會(huì)延緩犬貓的康復(fù)。臨床上特異性治療不會(huì)恢復(fù)患病犬貓的新陳代謝機(jī)能。所以促進(jìn)新陳代謝的支持治療性藥物會(huì)明顯促進(jìn)患病寵物的康復(fù)。,患病犬貓需要額外的能量來幫助疾病康復(fù),總結(jié),簡(jiǎn)而言之:患病動(dòng)物需要更多的能量: 正常的身體功能需要 從疾病中快速康復(fù)

2、,支持治療形式,平衡營(yíng)養(yǎng) 充足休息 注意管理 增加多種維生素和礦物質(zhì) 保護(hù)肝臟等,ENERGY,脂類和糖類最終利用的形式 (ATP),ATP 變成ADP并釋放細(xì)胞利用的能量 (如:提供給肌肉細(xì)胞),能量的利用方式,能量重要的因素,整個(gè)新陳代謝過程關(guān)鍵因素是磷元素的代謝,磷元素在AMP-ADP-ATP循環(huán)后,有部分會(huì)流失掉,理論上,磷元素加入到ADP分子中是提供能量?jī)?chǔ)備的最好方式,能量 理想的支持治療,磷會(huì)流失,需要不斷補(bǔ)充,提供含能量?jī)?chǔ)備的磷能幫助細(xì)胞更好的工作!,隨著能量需求的增加,富含能量的磷混合物可以滿足新陳代謝的需求,CATOSAL就是答案,每 ml含量: 布他磷 100.00 mg

3、Vit B12 0.05 mg Methyl paraben 1.00 mg,Phosphorus content: 17.3 mg/ml,提供磷元素,提供維生素,其他,作用成分,磷含量: 17.3 mg/ml,Catosal 疾病支持治療的關(guān)鍵,科特壯的成分,布他磷,有機(jī)磷酸 無味的白色晶體,VB12,科特壯的成分,布他磷,無味的白色晶體,作用機(jī)理 通過促進(jìn)ADP-ATP循環(huán)，促進(jìn)機(jī)體能量 代謝。 促進(jìn)機(jī)體的合成代謝過程。 激活犬貓機(jī)體非特異性免疫反應(yīng) 恢復(fù)疲勞肌肉功能。,緩解應(yīng)激 / 降低激素水平,De Groot J., van Der Werf J., van Reenen C., S

4、chuurman T., Schmidt B. (2003) : The effect of butafosfan (component of Catosal) on psychosocial stress in pigs. J. Vet. Pharmacol. Therap. 26 (Suppl. 1), 222-223. Van der Staay J., De Groot J., Schmidt B., Schuurman T. (2006) : Effects of Catosal on the physiological and behavioral response to soci

5、al stress in piglets. Proceedings of the 19th IPVS Congress, Copenhagen, Denmark, Volume 2. Simon F (1990) : Study on stress reducing effect of butafosfan in sheep. Institut fr Pharmakologie und Toxikologie, Veterinrmedizinische Universitt, Budapest, Hungary. Bayer ID 12765. Hnsel A., Fuhrmann H., S

6、allmann H.-P, Klee W. (1992) : Infusion von Propionate and Butyrat als Belastungstest zur berprfung mglicher Butafosfanwirkungen auf den Energiestoffwechsel des Rindes. Berl. Mnch. Tierrztl. Wschr. 105, 361-366. Hasi Su-rong, DU Xiao-yan, ZHU Bei-lei, JIANG Jin-shu (2004a): Studies on Effects of Com

7、pound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice. Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294.,降低冷熱刺激,Stress Reduction / control of cortisol increase,.,布他磷作用于組織缺氧,Hasi Su-rong et al. (2004a),*p:0.05, *p:0.001 compared to control group,*,*,存活時(shí)間 (分鐘),High

8、 dose butaphosphan (n=12) : 250 mg/kg butaphosphan once a day for 7 days orally. Low dose butaphosphan (n=12) 125 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12): 10 ml/kg physiologic saline once a day for 7 days oral. One hour after treatment on the last day, each mouse was pl

9、aced In a 300 ml wide-mouthed flask which was sealed with transparent glad wrap That did not admit air and timing was commenced. With the termination of breathing as the endpoint, the time for each mouse to expire from lack of oxygen was noted, so as to determine the effect of butaphosphan on the to

10、lerance of mice hypoxia.,刺激能量產(chǎn)生,參考資料: Hasi Su-rong, DU Xiao-yan, ZHU Bei-lei, JIANG Jin-shu (2004a): Studies on Effects of Compound Butaphosphan Solution on Endurance Capability and Energy Metabolism in Mice. Acta Veterinaria Et Zootechnica Sinica, 35 (03 ), 290-294. HASI Su-rong , JIANG Jin-shu, DU

11、 Xiao-yan, ZHU Bei-lei (2005a): Anti-cold stress effects and mechanisms of compound butaphosphan solution. Progress in Veterinary Medicine, 26, (03), 59-62. HASI Su-rong , JIANG Jin-shu , ZHU Bei-lei , DU Xiao-yan (2005b) : Studies on Anti-Heat Stress Effects and Mechanisms of Compound Butafosfan So

12、lution. Acta Veterinaria Et Zootechnica Sinica, 36 (12), 1334-1338.,Experiment 1(n=12): 250 mg/kg butaphosphan once a day for 7 days orally. Experiment 2 (n=12): 125 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12) : 10 ml/kg physiologic saline solution. One hour after last trea

13、tment on the last day, mice were sacrificed and liver glycogen content was determined via spectrometer,Experiment 1(n=12): 250 mg/kg butaphosphan once a day for 7 days orally. Experiment 2 (n=12): 125 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12) : 10 ml/kg physiologic saline

14、 solution. One hour after last treatment on the last day, mice were sacrificed and muscle glycogen content was determined via spectrometer,Butaphosphan treatment group (n=12): 250 mg/kg butaphosphan once a day for 7 days orally. Control group (n=12) : 10 ml/kg physiologic saline solution. One hour a

15、fter last treatment on the last day, mice were sacrificed and muscle ATP content was determined via HPLC.,提高肝臟功能,Studies Frll M., Witteck Th., Gengenbach S., Schmidt B. (2006) : Effects of pre-operative application of butaphosphan and cyanocobalamine on reconvalescence clinico-chemical parameters, a

16、ntioxidavive metabolism and postoperative abomosal emptying in cows with abomosal dislocation. Tierrztl. Prax. 34 (G): 351-356. HASI Su-rong , JIANG Jin-shu, DU Xiao-yan, ZHU Bei-lei (2005a): Anti-cold stress effects and mechanisms of compound butaphosphan solution. Progress in Veterinary Medicine,

17、26, (03), 59-62. HASI Su-rong , JIANG Jin-shu , ZHU Bei-lei , DU Xiao-yan (2005b) : Studies on Anti-heat Stress Effects and Mechanisms of Compound Butafosfan Solution. Acta Veterinaria Et Zootechnica Sinica, 36 (12), 1334-1338. Sommer H., Marx D., und Starker G. (1971) : Studies to reduce reproducti

18、ve disorders in cattle by using Catosal as metaphylaxis. Dtsch. Tierrtzl.Wschr. 78, 593 616. Flasshoff F.-H. (1974) : Clinical and chemical blood serum investigations in cattle and treatment studies with ornithine-aspartate-product HMV 20 and with Catosal for the reduction of fertility and health di

19、sorders. Doctorate Thesis, Tierrztliche Hochschule Hannover, Germany. Marbach W (1980) : Alkalische Phosphatase (AP) und Aspartataminotransferase (AST) des Blutplasmas als Parameter der Kondition von Rennpferden und die Wirkung von Coforta/Catosal auf diese Enzyme. Vet. Med. Nahchr., 12.,CATOSAL: 營(yíng)養(yǎng)

20、肝臟,谷草轉(zhuǎn)氨酶(ASAT)是一種線粒體內(nèi)的酶，當(dāng)肝臟或肌肉損傷或肝臟代謝負(fù)擔(dān)過重是會(huì)釋放到血液中。 科特壯能促進(jìn)糖異生的過程，這樣減輕肝臟的負(fù)擔(dān)。,0d,1d,2d,3d,post OP,科特壯-藥理作用,CATOSAL: 營(yíng)養(yǎng)肝臟,血液中的游離脂肪酸含量是脂肪代謝的指標(biāo)，脂肪代謝不好時(shí)其含量高 用科特壯治療后游離脂肪酸含量比未治療明顯降低,Catosal 藥理作用,科特壯的成分,VB12,水溶性,提供鈷元素 需要不斷攝入,作用方式 調(diào)節(jié)蛋白質(zhì)、脂類和碳水化合物的新陳代謝 提供鈷元素，幫助紅細(xì)胞合成。 促進(jìn)蛋氨酸合成，而蛋氨酸是機(jī)體蛋白質(zhì)重要的合成原料。 促進(jìn)身體生長(zhǎng),提高食物利用率。,黑色晶體,吸水性,科特壯-藥理作用,CATOSAL: 抗氧化作用,布他磷是一種-氨基磷酸,可以保護(hù)犬貓機(jī)體免受氧化損傷。,CATOSAL: 促進(jìn)生長(zhǎng)發(fā)育,布他磷能夠影響寵物的中間代謝（GIESECKE 1985），主要表現(xiàn)為促進(jìn)能量代謝、提高蛋白質(zhì)合成（K