1、 HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html Amyloid-amyloid peptide; A; AbetaAmyloid- (A) denotes peptides of 3643 amino acids that are crucially involved in Alzheimers disease as the main component oftheamyloid plaques found in the brains of Alzheimer patients. The peptides result from the

2、 amyloid precursor protein (APP), whichis being cut by certain enzymes to yield A. Amyloid- molecules can aggregate to form flexible soluble oligomers which may existin several forms. Amyloid- peptide is due to overproduction of A and/or the failure of clearance mechanisms. Amyloid-self-aggregates i

3、nto oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and bloodvessels. Amyloid- oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alterintracellular Ca2+levels and stimulate inflammatory proces

4、ses. Loss of the normal physiological functions of A is also thought tocontribute to neuronal dysfunction.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html Amyloid- HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html Inhibitors, HY

5、PERLINK https:/www.MedChemE/Targets/Amyloid-.html HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html Agonists, HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html HYPERLINK https:/ww

6、w.MedChemE/Targets/Amyloid-.html Activators HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html & HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html HYPERLINK https:/www.MedChemE/Targets/Amyloid-.html Chemicals HYPERLINK https:/www.MedChemE/r-plus

7、-anatabine.html (R)-(+)-Anatabine HYPERLINK https:/www.MedChemE/r-plus-anatabine.html HYPERLINK https:/www.MedChemE/2-hydroxy-5-phenyldiazenyl-benzoic-acid-d5.html 2-Hydroxy-5-(phenyldiazenyl)benzoic HYPERLINK https:/www.MedChemE/2-hydroxy-5-phenyldiazenyl-benzoic-acid-d5.html HYPERLINK https:/www.M

8、edChemE/2-hydroxy-5-phenyldiazenyl-benzoic-acid-d5.html acid-d5Cat. No.: HY-126047B Cat. No.: HY-W013425S(R)-(+)-Anatabine is an less active R-enantiomerof Anatabine. Anatabine is a potent 42 nAChRagonist. Anatabine inhibits NF-B activationlower amyloid- (A) production by preventingthe -cleavage of

9、amyloid precursor protein (APP).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 50 mg HYPERLINK https:/www.MedChemE/Ginsenoside-Rg3.html 20(S)-Ginsenoside HYPERLINK https:/www.MedChemE/Ginsenoside-Rg3.html HYPERLINK https:

10、/www.MedChemE/Ginsenoside-Rg3.html Rg3(20(S)-Propanaxadiol; S-ginsenoside Rg3) Cat. No.: HY-N0603 HYPERLINK https:/www.MedChemE/4-_6-Bromo-2-benzothiazolyl_-N-methylbenzenamine.html 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamineCat. No.: HY-11151320(S)-Ginsenoside Rg3 is the main component of Redg

11、inseng. Ginsenoside Rg3 inhibits Na+ andhKv1.4 channel with IC s of 32.24.5 and 32.62.250M, respectively. 20(S)-Ginsenoside Rg3 alsoinhibits A levels, NF-B activity, and COX-2expression.4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamineis a potent amyloid imaging agent which binds toAmyloid- (1-40) wi

12、th a K of 1.7 nM.DPurity: 98.10%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98.60%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/4-_6-Bromo-2-benzothiazolyl_benzenamine.html 4-(6-Bromo-2-benzothiazolyl)benzenamine HYPERLINK https:/www.Me

13、dChemE/4-_6-Bromo-2-benzothiazolyl_benzenamine.html HYPERLINK https:/www.MedChemE/ac-253.html AC HYPERLINK https:/www.MedChemE/ac-253.html HYPERLINK https:/www.MedChemE/ac-253.html 253Cat. No.: HY-111514 Cat. No.: HY-P22854-(6-Bromo-2-benzothiazolyl)benzenamine is a-amyloid PET (positron emission to

14、mography)tracer that can be used in the diagnosis ofneurological diseases, such as Alzheimers andDowns syndrome.AC 253, an amylin antagonist, inhibits125I-adrenomedullin binding, with an IC of 2550nM.Purity: 97.0%Clinical Data: No Development ReportedSize: 10 mg, 50 mgPurity: 98%Clinical Data: No De

15、velopment ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ache-in-12.html AChE-IN-12 HYPERLINK https:/www.MedChemE/ache-in-12.html HYPERLINK https:/www.MedChemE/aducanumab.html AducanumabCat. No.: HY-144790(BIIB037) Cat. No.: HY-P9967AChE-IN-12 is a potent and blood-brain barrier(BBB) penetra

16、nt acetylcholinesterase (AChE) withIC s of 0.41 M and 1.88 M for rat AChE and50electric eel AChE.Aducanumab (BIIB037), a human monoclonal antibodyselective for aggregated forms of amyloid beta(A). Aducanumab shows brain penetration, and canbe used for Alzheimers disease (AD) research.Purity: 98%Clin

17、ical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Aftin-4.html Aftin-4 HYPERLINK https:/www.MedChemE/Aftin-4.html HYPERLINK https:/www.MedChemE/alz-801.html ALZ-801Cat. No.: HY-111267 Cat. No.: HY-117259Aftin-4 is an Am

18、yloid- ( ) inducer.42 A42ALZ-801 is a potent and orally availablesmall-molecule -amyloid (A) anti-oligomerand aggregation inhibitor, valine-conjugatedprodrug of Tramiprosate with substantiallyimproved PK properties and gastrointestinaltolerability compared with the parentPurity: 98.03%Clinical Data:

19、 No Development ReportedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.0%Clinical Data: Phase 3Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/amyloid-P-IN-1.html amyloid HYPERLINK https:/www.MedChem

20、E/amyloid-P-IN-1.html HYPERLINK https:/www.MedChemE/amyloid-P-IN-1.html P-IN-1 HYPERLINK https:/www.MedChemE/amyloid-P-IN-1.html HYPERLINK https:/www.MedChemE/anatabine-dicitrate.html Anatabine HYPERLINK https:/www.MedChemE/anatabine-dicitrate.html HYPERLINK https:/www.MedChemE/anatabine-dicitrate.h

21、tml dicitrateCat. No.: HY-19771 Cat. No.: HY-19918Aamyloid P-IN-1 is used in the research of diseasesor disorders wherein depletion of serum amyloid Pcomponent (SAP), including amyloidosis,Alzheimers disease, type 2 diabetes mellitus andosteoarthritis.Anatabine dicitrate is a tobacco alkaloid that c

22、ancross the blood-brain barrier. Anatabine dicitrateis a potent 42 nAChR agonist.Purity: 99.91%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.24%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www

23、.MedChemE/Anle138b.html Anle138b HYPERLINK https:/www.MedChemE/Anle138b.html HYPERLINK https:/www.MedChemE/antioxidant-agent-2.html Antioxidant HYPERLINK https:/www.MedChemE/antioxidant-agent-2.html HYPERLINK https:/www.MedChemE/antioxidant-agent-2.html agent-2Cat. No.: HY-101855 Cat. No.: HY-145888

24、Anle138b, an oligomeric aggregation inhibitor,blocks the formation of pathological aggregates ofprion protein (PrPSc) and of -synuclein (-syn).Anle138b strongly inhibits oligomer accumulation,neuronal degeneration, and disease progression invivo.Antioxidant agent-2 (comp 3c), an BBB-penetratedantiox

25、idant agent and a selective metal ionschelator, presents good neuroprotective effect andhepatoprotective effect for the study ofAlzheimers disease.Purity: 99.96%Clinical Data: Phase 1Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 m

26、g, 5 mg HYPERLINK https:/www.MedChemE/ARN2966.html ARN2966Cat. No.: HY-18292 HYPERLINK https:/www.MedChemE/azd4694.html AZD4694(NAV4694) Cat. No.: HY-113938ARN2966 is a potent post-transcriptional modulatorof APP expression; reduces expression of APP withresultant lower production of A.AZD4694 (NAV4

27、694), a fluorinated -amyloid (A)plaque neuroimaging PET radioligand, shows highaffinity for A fibrils (K = 2.3 nM).dPurity: 99.57%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.M

28、edChemE/Azeliragon.html Azeliragon HYPERLINK https:/www.MedChemE/Azeliragon.html HYPERLINK https:/www.MedChemE/a-fibrillization-modulator-1.html A HYPERLINK https:/www.MedChemE/a-fibrillization-modulator-1.html HYPERLINK https:/www.MedChemE/a-fibrillization-modulator-1.html Fibrillization HYPERLINK

29、https:/www.MedChemE/a-fibrillization-modulator-1.html HYPERLINK https:/www.MedChemE/a-fibrillization-modulator-1.html modulator HYPERLINK https:/www.MedChemE/a-fibrillization-modulator-1.html HYPERLINK https:/www.MedChemE/a-fibrillization-modulator-1.html 1(TTP488; PF-04494700) Cat. No.: HY-50682Cat

30、. No.: HY-139740Azeliragon (TTP488) is an orally bioavailableinhibitor of the receptor for advanced glycationend products (RAGE) in development as a potentialtreatment to slow disease progression in patientswith mild Alzheimers disease (AD). Azeliragonalso can cross the blood-brain barrier (BBB).A F

31、ibrillization modulator 1 stabilizes Amonomers.Purity: 99.70%Clinical Data: Phase 3Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/a-in-1.html A-IN-1 HYPERLINK https:/www.MedChemE/a-in-1.html HYPERLINK https:

32、/www.MedChemE/a-in-2.html A-IN-2Cat. No.: HY-144326 Cat. No.: HY-144327A-IN-1 is a A142 aggregation inhibitor. A-IN-1inhibits A1-42 self-aggregation invitro by delaying the exponential growthphase or reduces the quantity of fibrils in thesteady state. A-IN-1 can be used for theresearch of conformati

33、onal disorders.A-IN-2 is a A142 aggregation inhibitor. A-IN-2inhibits A1-42 self-aggregation invitro by delaying the exponential growthphase or reduces the quantity of fibrils in thesteady state. A-IN-2 can be used for theresearch of conformational disorders.Purity: 98%Clinical Data: No Development

34、ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/a-tau-aggregation-in-1.html A/tau HYPERLINK https:/www.MedChemE/a-tau-aggregation-in-1.html HYPERLINK https:/www.MedChemE/a-tau-aggregation-in-1.html aggregation-IN-1

35、 HYPERLINK https:/www.MedChemE/a-tau-aggregation-in-1.html HYPERLINK https:/www.MedChemE/BF_227.html BF HYPERLINK https:/www.MedChemE/BF_227.html HYPERLINK https:/www.MedChemE/BF_227.html 227Cat. No.: HY-141661 Cat. No.: HY-105252AA/tau aggregation-IN-1 is a potent A1-42-sheets formation and tau agg

36、regationinhibitor. The K values of A/tauDaggregation-IN-1 with A and are 160 M1-42 tauand 337 M, respectively. A/tau aggregation-IN-1can permeate the blood-brain barrier.BF 227 is a candidate for an amyloid imaging probefor PET, with a K of 4.3 nM for .i A1-42 fibrilsPurity: 98%Clinical Data: No Dev

37、elopment ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.67%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/BF-168.html BF-168 HYPERLINK https:/www.MedChemE/BF-168.html HYPERLINK https:/www.MedChemE/buche-i

38、n-2.html BuChE-IN-2Cat. No.: HY-112830 Cat. No.: HY-143413BF-168, a candidate probe for PET, is found tospecifically recognize both neuritic and diffuseplaques, with a K of 6.4 nM for .i A1-42BuChE-IN-2 is an excellent butyrylcholinesterase(BuChE) inhibitor (IC s of 1.28 M and 0.67 M50for BuChE and

39、NO). BuChE-IN-2 can inhibit theaggregation of A, ROS formation and chelateCu2+, exhibiting proper blood-brain barrier (BBB)penetration.Purity: 99.39%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLIN

40、K https:/www.MedChemE/carbenoxolone-d4.html Carbenoxolone-d4Cat. No.: HY-B1588S HYPERLINK https:/www.MedChemE/cgp52411.html CGP52411(DAPH) Cat. No.: HY-103442Carbenoxolone-d4 is deuterium labeledCarbenoxolone. Carbenoxolone, a semi-syntheticderivative of glycyrrhetinic acid, has previouslybeen used

41、for the management of dyspepsia andpeptic ulcer because of its anti-inflammatoryproperties.CGP52411 (DAPH) is a high selective, potent,orally active and ATP-competitive EGFR inhibitorwith an IC of 0.3 M.50Purity: 98%Clinical Data:Size: 1 mg, 5 mgPurity: 99.82%Clinical Data: No Development ReportedSi

42、ze: 10 mM 1 mL, 5 mg HYPERLINK https:/www.MedChemE/che-a1-42-in-1.html ChE/A1-42-IN-1 HYPERLINK https:/www.MedChemE/che-a1-42-in-1.html HYPERLINK https:/www.MedChemE/cl-nqtrp.html Cl-NQTrpCat. No.: HY-144388 Cat. No.: HY-138643ChE/A1-42-IN-1 (compound 28) is a potent ChE andA1-42 IC50aggregation inh

43、ibitor with s of0.062, 0.767 and 1.227 M for AChE, BuChE andA aggregation, respectively. ChE/1-42-IN-11-42shows excellent BBB penetration. ChE/A1-42-IN-1is a potent multi-targeted anti-Alzheimers agent.Cl-NQTrp signifcantly disrupts the preformedfbrillar aggregates of Tau-derived PHF6 (VQIVYK)peptid

44、e and full-length tau protein.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Colivelin.html Colivelin HYPERLINK https:/www.MedChemE/Colivelin.html HYPERLINK https:

45、/www.MedChemE/Colivelin_TFA.html Colivelin HYPERLINK https:/www.MedChemE/Colivelin_TFA.html HYPERLINK https:/www.MedChemE/Colivelin_TFA.html TFACat. No.: HY-P1061 Cat. No.: HY-P1061AColivelin is a brain penetrant neuroprotectivepeptide and a potent activator of STAT3,suppresses neuronal death by act

46、ivatingSTAT3 in vitro.Colivelin TFA is a brain penetrant neuroprotectivepeptide and a potent activator of STAT3,suppresses neuronal death by activatingSTAT3 in vitro.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.22%Clinical Data: No Development ReportedSize: 500 g, 1 mg

47、4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/cranad-2.html CRANAD-2 HYPERLINK https:/www.MedChemE/cranad-2.html HYPERLINK https:/www.MedChemE/cu-ii-gtsm.html Cu(II)GTSMCat. No.: HY-103242 Cat. No.: HY-139324CRANAD-2 is a near-infrared (NIR) Aplaque-specifi

48、c fluorescent probe. CRANAD 2penetrates the blood brain barrier and has a highaffinity for A aggregates with a K of 38 nM.dCu(II)GTSM, a cell-permeable Cu-complex,significantly inhibits GSK3. Cu(II)GTSM inhibitsAmyloid- oligomers (AOs) and decreases tauphosphorylation. Cu(II)GTSM also decreases thea

49、bundance of Amyloid- trimers. Cu(II)GTSM is apotential anticancer and antimicrobial agent.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/DAPT.html DAPT(GSI-IX) Cat. No.: HY-13027 HYPERLI

50、NK https:/www.MedChemE/davunetide.html DavunetideCat. No.: HY-105066DAPT (GSI-IX) is a potent and orally active-secretase inhibitor with IC s of 115 nM and50200 nM for total amyloid- (A) and A ,42respectively. DAPT inhibits the activation ofNotch 1 signaling and induces celldifferentiation.Davunetid

51、e is an eight amino acid snippet derivedfrom activity-dependent neuroprotective protein(ADNP), a neurotrophic factor that exists in themammalian CNS. Davunetide possessesneuroprotective, neurotrophic and cognitiveprotective roperties.Purity: 99.93%Clinical Data: No Development ReportedSize: 10 mM 1

52、mL, 5 mg, 10 mg, 50 mgPurity: 98.85%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/dc-chol-hydrochloride.html DC-Chol HYPERLINK https:/www.MedChemE/dc-chol-hydrochloride.html HYPERLINK https:/www.MedChemE/dc-chol-hydrochloride.html hydrochloride(DC

53、-Cholesterol hydrochloride) Cat. No.: HY-137131 HYPERLINK https:/www.MedChemE/Deferoxamine-mesylate.html Deferoxamine HYPERLINK https:/www.MedChemE/Deferoxamine-mesylate.html HYPERLINK https:/www.MedChemE/Deferoxamine-mesylate.html mesylate(Desferrioxamine B mesylate; DFOM) Cat. No.: HY-B0988DC-Chol

54、 hydrochloride could inhibit A40 fibrilformation under appropriate experimentalconditions. DC-Chol hydrochloride stronglyinhibits amyloidogenesis of oxidized hCT in adose-dependent manner.Deferoxamine mesylate is an iron chelator thatbinds free iron in a stable complex, preventing itfrom engaging in

55、 chemical reactions.Purity: 98%Clinical Data: No Development ReportedSize: 100 mgPurity: 99.86%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 500 mg HYPERLINK https:/www.MedChemE/dihydroergocristine-mesylate.html Dihydroergocristine HYPERLINK https:/www.MedChemE/dihydroergocristine-mesylate.html H

56、YPERLINK https:/www.MedChemE/dihydroergocristine-mesylate.html mesylate HYPERLINK https:/www.MedChemE/dihydroergocristine-mesylate.html HYPERLINK https:/www.MedChemE/Edonerpic_maleate.html Edonerpic HYPERLINK https:/www.MedChemE/Edonerpic_maleate.html HYPERLINK https:/www.MedChemE/Edonerpic_maleate.

57、html maleate(DHEC mesylate) Cat. No.: HY-N2319 (T-817 maleate; T-817MA) Cat. No.: HY-17631ADihydroergocristine mesylate (DHEC mesylate) is ainhibitor of -secretase (GSI), reduces theproduction of the Alzheimers disease amyloid-peptides, binds directly to -secretase andNicastrin with equilibrium diss

58、ociation constants(K ) of 25.7 nM and 9.8 M, respectively.dPurity: 99.86%Clinical Data: LaunchedSize: 10 mM 1 mL, 5 mg, 10 mgEdonerpic maleate is a novel neurotrophic agentwhich can inhibit amyloid- peptides (A).Purity: 98.68%Clinical Data: Phase 2Size: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg H

59、YPERLINK https:/www.MedChemE/fmoc-ala-glu-asn-lys-nh2.html Fmoc-Ala-Glu-Asn-Lys-NH2 HYPERLINK https:/www.MedChemE/fmoc-ala-glu-asn-lys-nh2.html HYPERLINK https:/www.MedChemE/FPS-ZM1.html FPS-ZM1Cat. No.: HY-114174 Cat. No.: HY-19370Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagineendopeptidase (AEP

60、) inhibitor peptide andsuppresses amyloid precursor protein (APP)cleavage. AEP, a pH-controlled cysteineproteinase, is activated during ageing andmediates APP proteolytic processing.FPS-ZM1 is a high-affinity RAGE inhibitor with aK of 25 nM.iPurity: 98.04%Clinical Data: No Development ReportedSize: