1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-(+)-ArabinoseCat. No.: HY-W015611CAS No.: 5328-37-0分式: CHO分量: 150.13作靶點(diǎn): Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 500 mg/mL (3330.

2、45 mM; Need ultrasonic)DMSO : 50 mg/mL (333.04 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 6.6609 mL 33.3045 mL 66.6089 mL5 mM 1.3322 mL 6.6609 mL 13.3218 mL10 mM 0.6661 mL 3.3304 mL 6.6609 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄的儲(chǔ)備

3、液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (16.65 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (16.65 mM); Clear solution3. 請(qǐng)依序添加每種溶劑

4、： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (16.65 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 L-(+)-Arabinose 有選擇性的抑制腸道蔗糖酶的活性，并抑制因蔗糖攝導(dǎo)致的漿葡萄糖增加。IC50 & Target Human Endogenous Metabolite體外研究 L-(+)-Arabinose selectively inhibits intestinal sucrase activi

5、ty in a noncompetitive manner and suppresses theplasma glucose increase due to sucrose ingestion 1. L-(+)-Arabinose is found to be associated with ribose-5-phosphate isomerase deficiency, which is an inborn error of metabolism 2.REFERENCES1. Osaki S, et al. L-arabinose feeding prevents increases due

6、 to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats. JNutr. 2001 Mar;131(3):796-9.2. Huck JH, et al. Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowlyprogressive leukoencephalopathy. Am J Hum Genet. 2004 Apr;74(4):745-51.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 4